Nick's take:
The Bills' strength on offense is its tailbacks, and the Patriots' strength on defense is run-stopping. Conversely, Buffalo's Ryan Fitzpatrick-led passing offense isn't scary at all, but neither is New England's porous pass defense. That makes for an interesting matchup, though quarterback Tom Brady and the Patriots' offense is as capable as it gets, so that'll be the difference against a very bad Bills defense.
Prediction: Patriots 30, Bills 14
Dan's take:
Prediction: Patriots 34, Bills 24
Sean's take:
In each of the past two matchups between these long-time rivals, the Bills have gone into halftime with a seven-point lead. However, they have then been outscored 80-14 in the final two quarters of those games. This week's edition will feel like business as usual as Brady out-guns Fitzpatrick en route to another convincing victory.
Prediction: Patriots 35, Bills 17
Prediction: Patriots 35, Bills 17