Nick's take:

Prediction: Patriots 35, Colts 24
Dan's take:
Luck's been impressive of late, but he hasn't faced an opponent as complete as the Patriots since Week 1 in his ugly debut against the Chicago Bears. Luck and receiver Reggie Wayne will get their shots downfield against a terrible big-play defense, but running back Stevan Ridley and New England's dynamic passing attack will be too much for an Indianapolis defense allowing 350 yards per game.

Prediction: Patriots 34, Colts 27
As a rookie, Luck has proven that he will be near the top of the next generation of NFL passers. He will show that he is a worthy opponent for Brady, but in the end, the future hall-of-famer will engineer a victory for the hometown Patriots. But this game will be a thriller, and may be a playoff-matchup preview.
Prediction: Colts 24, Patriots 21
Sean's take:

Prediction: Colts 24, Patriots 21