Dan's take:

Nick's take:

Prediction: Saints 37, Bills 20
Sean's take:
Coming off their bye, the Saints look to get back on track after dramatically losing their undefeated status at the hands of the Patriots two weeks ago. For the Buffalo defense, a well-rested, well prepared Brees-led offense on the Superdome turf will be too much of a challenge, with or without the star tight end. New Orleans blows this game open early and never looks back.
Coming off their bye, the Saints look to get back on track after dramatically losing their undefeated status at the hands of the Patriots two weeks ago. For the Buffalo defense, a well-rested, well prepared Brees-led offense on the Superdome turf will be too much of a challenge, with or without the star tight end. New Orleans blows this game open early and never looks back.
Prediction: Saints 41, Bills 24